Professor of Psychology, College of Literature, Science, and the Arts, Research Professor, Center for Human Growth and Development, Professor of Psychiatry, Medical School and Research Professor, Survey Research Center, Institute for Social Research
Biography
Dr. Monk uses behavioral and neuroimaging methods to examine affective-cognitive processing during adolescent development. In particular, his research focuses on how behavioral and brain-based responses vary with age in normally developing youth as well as those with or at risk for psychopathology.
Adolescence is a period of exceptional mental capacities relative to earlier ages, but it is also an age of increased risk for emotion-based mental conditions, such as depression and anxiety. The ultimate goal of this research program is to better understand why some adolescents effectively navigate their emotionally-charged surroundings, while others struggle and a subset experience the first onset of long-term mental disorders. Through a better understanding of the behavioral and neural events that underlie the emergence of these pathways, it may be possible to design better diagnostic tests, implement novel treatments that more precisely target underlying pathophysiology, and potentially prevent initial onset through early intervention.
Funded Research
- Effects of poverty on affective development: A multi-level, longitudinal study
- Effects of poverty on affective development: A multi-level, longitudinal study
- Effects of poverty on affective development: A multi-level, longitudinal study
- Epigenetic Mediation of Adverse Social Context on Stress Response, Socioemotional Development, and Health in a Population-based Study of Minority and Low SES Children and Adolescents
- Neurodevelopmental Pathways in Adolescent Health Risk Behavior
Publications
- Burkhouse, Katie L.; Stange, Jonathan P.; Jacobs, Rachel H.; Bhaumik, Runa; Bessette, Katie L.; Peters, Amy T.; Crane, Natania A.; Kreutzer, Kayla A.; Fitzgerald, Kate; Monk, Christopher S.; Welsh, Robert C.; Phan, K. Luan; Langenecker, Scott A. (2019). Developmental changes in resting-state functional networks among individuals with and without internalizing psychopathologies. Depression and Anxiety, 36(2), 141-152.
- Peters, Amy T.; Burkhouse, Katie L.; Kujawa, Autumn; Afshar, Kaveh; Fitzgerald, Kate D.; Monk, Christopher S.; Hajcak, Greg; Phan, K. L. (2019). Impact of pubertal timing and depression on error-related brain activity in anxious youth. Developmental psychobiology, 61(1), 69-80.
- Hein, Tyler C.; Mattson, Whitney I.; Dotterer, Hailey L.; Mitchell, Colter M.; Lopez-Duran, Nestor; Thomason, Moriah E.; Peltier, Scott J.; Welsh, Robert C.; Hyde, Luke W.; Monk, Christopher S. (2018). Amygdala habituation and uncinate fasciculus connectivity in adolescence: A multi-modal approach. NeuroImage, 183, 617-626.
- Bunford, Nóra; Kujawa, Autumn; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. Luan (2018). Convergence of BOLD and ERP measures of neural reactivity to emotional faces in children and adolescents with and without anxiety disorders. Biological psychology, 134, 9-19.
- Burkhouse, Katie L.; Kujawa, Autumn; Hosseini, Bobby; Klumpp, Heide; Fitzgerald, Kate D.; Langenecker, Scott A.; Monk, Christopher S.; Phan, K. Luan (2018). Anterior cingulate activation to implicit threat before and after treatment for pediatric anxiety disorders. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 84, Part A, 250-256.
- Velasquez, Francisco; Wiggins, Jillian Lee; Mattson, Whitney I.; Martin, Donna M.; Lord, Catherine; Monk, Christopher S. (2017). The influence of 5-HTTLPR transporter genotype on amygdala-subgenual anterior cingulate cortex connectivity in autism spectrum disorder. Developmental Cognitive Neuroscience, 24, 12-20.
- Bunford, Nora; Kujawa, Autumn; Fitzgerald, Kate D.; Swain, James E.; Hanna, Gregory L.; Koschmann, Elizabeth; Simpson, David; Connolly, Sucheta; Monk, Christopher S.; Phan, K. L. (2017). Neural Reactivity to Angry Faces Predicts Treatment Response in Pediatric Anxiety. Journal of abnormal child psychology, 45(2), 385-395.
- Bunford, Nora; Kujawa, Autumn; Swain, James E.; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. L. (2017). Attenuated neural reactivity to happy faces is associated with rule breaking and social problems in anxious youth. European child & adolescent psychiatry, 26(2), 215-230.
- Burkhouse, Katie L.; Kujawa, Autumn; Keenan, Kate; Klumpp, Heide; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. Luan (2017). The relation between parent depressive symptoms and neural correlates of attentional control in offspring: A preliminary study. Psychiatry Research: Neuroimaging, 263, 26-31.
- Burkhouse, Katie L.; Kujawa, Autumn; Klumpp, Heide; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. L. (2017). Neural correlates of explicit and implicit emotion processing in relation to treatment response in pediatric anxiety. Journal of Child Psychology and Psychiatry, 58(5), 546-554.
- Hein, Tyler C.; Monk, Christopher S. (2017). Research Review: Neural response to threat in children, adolescents, and adults after child maltreatment – quantitative meta-analysis. Journal of Child Psychology and Psychiatry, 58(3), 222-230.
- Kujawa, Autumn; E, James Swain; L, Gregory Hanna; Koschmann, Elizabeth; Simpson, David; Connolly, Sucheta; D, Kate Fitzgerald; Monk, Christopher S.; Phan, K. Luan (2016). Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth. Neuropsychopharmacology, 41(8), 1983-1990.
- Kujawa, Autumn; Weinberg, Anna; Bunford, Nora; Fitzgerald, Kate D.; Hanna, Gregory L.; Monk, Christopher S.; Kennedy, Amy E.; Klumpp, Heide; Hajcak, Greg; Phan, K. Luan (2016). Error-related brain activity in youth and young adults before and after treatment for generalized or social anxiety disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 71, 162-168.
- Kujawa, Autumn; Wu, Minjie; Klumpp, Heide; Pine, Daniel S.; Swain, James E.; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. Luan (2016). Altered Development of Amygdala-Anterior Cingulate Cortex Connectivity in Anxious Youth and Young Adults. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 1(4), 345-352.
- MacNamara, Annmarie; Vergés, Alvaro; Kujawa, Autumn; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. Luan (2016). Age-related changes in emotional face processing across childhood and into young adulthood: Evidence from event-related potentials. Developmental psychobiology, 58(1), 27-38.
- Mattson, Whitney I.; Hyde, Luke W.; Shaw, Daniel S.; Forbes, Erika E.; Monk, Christopher S. (2016). Clinical neuroprediction: Amygdala reactivity predicts depressive symptoms 2 years later. Social Cognitive and Affective Neuroscience, 11(6), 892-898.
- Wu, Minjie; Kujawa, Autumn; Lu, Lisa H.; Fitzgerald, Daniel A.; Klumpp, Heide; Fitzgerald, Kate D.; Monk, Christopher S.; Phan, K. L. (2016). Age-related changes in amygdala-frontal connectivity during emotional face processing from childhood into young adulthood. Human brain mapping, 37(5), 1684-1695.
- Kujawa, Autumn; MacNamara, Annmarie; Fitzgerald, KateD; Monk, Christopher S. and Phan, K. L. (2015). Enhanced Neural Reactivity to Threatening Faces in Anxious Youth: Evidence from Event-Related Potentials. Journal of Abnormal Child Psychology, 43(8), 1493-1501.
- Wiggins, Jillian L.; Mitchell, Colter M.; Hyde, Luke W. and Monk, Christopher S. (2015). Identifying Early Pathways of Risk and Resilience: The Codevelopment of Internalizing and Externalizing Symptoms and the Role of Harsh Parenting. Development and Psychopathology, 27(4), 1295-1312.
- Wiggins, J. L.; Swartz, J. R.; Martin, D. M.; Lord, C. and Monk, Christopher S. (2014). Serotonin Transporter Genotype Impacts Amygdala Habituation in Youth with Autism Spectrum Disorders. Social Cognitive and Affective Neuroscience, 9(6), 832-838.
- Wiggins, J. L.; Bedoyan, J. K.; Carrasco, M.; Swartz, J. R.; Martin, D. M. and Monk, Christopher S. (2014). Age-Related Effect of Serotonin Transporter Genotype on Amygdala and Prefrontal Cortex Function in Adolescence. Human Brain Mapping, 35(2), 646-658.
- Swartz, J. R.; Phan, K. L.; Angstadt, M.; Klumpp, H.; Fitzgerald, K. D. and Monk, Christopher S. (2014). Altered Activation of the Rostral Anterior Cingulate Cortex in the Context of Emotional Face Distractors in Children and Adolescents with Anxiety Disorders. Depression and Anxiety, 31(10), 870-879.
- Swartz, J. R.; Phan, K. L.; Angstadt, M.; Fitzgerald, K. D. and Monk, Christopher S. (2014). Dynamic Changes in Amygdala Activation and Functional Connectivity in Children and Adolescents with Anxiety Disorders. Development and Psychopathology, 26(4 Pt 2), 1305-1319.
- Swartz, J. R.; Carrasco, M.; Wiggins, J. L.; Thomason, M. E. and Monk, Christopher S. (2014). Age-Related Changes in the Structure and Function of Prefrontal Cortex-Amygdala Circuitry in Children and Adolescents: A Multi-Modal Imaging Approach. Neuroimage, 86, 212-220.
- Swartz, J. R. and Monk, Christopher S. (2014). The Role of Corticolimbic Circuitry in the Development of Anxiety Disorders in Children and Adolescents. Current Topics in Behavioral Neurosciences, 16, 133-148.
- Hamm, L. L.; Jacobs, R. H.; Johnson, M. W.; Fitzgerald, D. A.; Fitzgerald, K. D.; Langenecker, S. A.; Monk, Christopher S. and Phan, K. L. (2014). Aberrant Amygdala Functional Connectivity at Rest in Pediatric Anxiety Disorders. Biology of Mood & Anxiety Disorders, 4(1), 15.
- Di Martino, A.; Yan, C. G.; Li, Q.; Denio, E.; Castellanos, F. X.; Alaerts, K.; Anderson, J. S.; Assaf, M.; Bookheimer, S. Y.; Dapretto, M.; Deen, B.; Delmonte, S.; Dinstein, I.; Ertl-Wagner, B.; Fair, D. A.; Gallagher, L.; Kennedy, D. P.; Keown, C. L.; Keysers, C.; Lainhart, J. E.; Lord, C.; Luna, B.; Menon, V.; Minshew, N. J.; Monk, Christopher S.; Mueller, S.; Muller, R. A.; Nebel, M. B.; Nigg, J. T.; O'Hearn, K.; Pelphrey, K. A.; Peltier, S. J.; Rudie, J. D.; Sunaert, S.; Thioux, M.; Tyszka, J. M.; Uddin, L. Q.; Verhoeven, J. S.; Wenderoth, N.; Wiggins, J. L.; Mostofsky, S. H. and Milham, M. P. (2014). The Autism Brain Imaging Data Exchange: Towards a Large-Scale Evaluation of the Intrinsic Brain Architecture in Autism. Molecular Psychiatry, 19(6), 659-667.
- Bernard, J. A.; Peltier, S. J.; Benson, B. L.; Wiggins, J. L.; Jaeggi, S. M.; Buschkuehl, M.; Jonides, J.; Monk, Christopher S. and Seidler, R. D. (2014). Dissociable Functional Networks of the Human Dentate Nucleus. Cerebral Cortex, 24(8), 2151-2159.
- Wiggins, J. L. and Monk, Christopher S. (2013). A Translational Neuroscience Framework for the Development of Socioemotional Functioning in Health and Psychopathology. Development and Psychopathology, 25(4 Pt 2), 1293-1309.
- Swartz, J. R.; Wiggins, J. L.; Carrasco, M.; Lord, C. and Monk, Christopher S. (2013). Amygdala Habituation and Prefrontal Functional Connectivity in Youth with Autism Spectrum Disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1), 84-93.
- Fitzgerald, K. D.; Liu, Y.; Stern, E. R.; Welsh, R. C.; Hanna, G. L.; Monk, Christopher S.; Phan, K. L. and Taylor, S. F. (2013). Reduced Error-Related Activation of Dorsolateral Prefrontal Cortex Across Pediatric Anxiety Disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 52(11), 1183-1191.e1.
- Bernard, J. A.; Peltier, S. J.; Wiggins, J. L.; Jaeggi, S. M.; Buschkuehl, M.; Fling, B. W.; Kwak, Y.; Jonides, J.; Monk, Christopher S. and Seidler, R. D. (2013). Disrupted Cortico-Cerebellar Connectivity in Older Adults. Neuroimage, 83, 103-119.
- Falk, E. B.; Hyde, L. W.; Mitchell, Colter M.; Faul, Jessica D.; Gonzalez, R.; Heitzeg, M. M.; Keating, Daniel P.; Langa, Kenneth M.; Martz, M. E.; Maslowsky, J.; Morrison, Frederick J.; Noll, D. C.; Patrick, Megan E.; Pfeffer, Fabian T.; Reuter-Lorenz, P. A.; Thomason, M. E.; Davis-Kean, Pamela E.; Monk, Christopher S. and Schulenberg, John E. (2013). What is a Representative Brain? Neuroscience Meets Population Science. Proceedings of the National Academy of Sciences of the United States of America, 110(44), 17615-17622.
- Wiggins, J. L.; Peltier, S. J.; Bedoyan, J. K.; Carrasco, M.; Welsh, R. C.; Martin, D. M.; Lord, C.; Monk, Christopher S. and Monk, Christopher S. (2012). The Impact of Serotonin Transporter Genotype on Default Network Connectivity in Children and Adolescents with Autism Spectrum Disorders. NeuroImage.Clinical, 2, 17-24.
- Wiggins, J. L.; Bedoyan, J. K.; Peltier, S. J.; Ashinoff, S.; Carrasco, M.; Weng, S. J.; Welsh, R. C.; Martin, D. M. and Monk, Christopher S. (2012). The Impact of Serotonin Transporter (5-HTTLPR) Genotype on the Development of Resting-State Functional Connectivity in Children and Adolescents: A Preliminary Report. Neuroimage, 59(3), 2760-2770.
- Bernard, J. A.; Seidler, R. D.; Hassevoort, K. M.; Benson, B. L.; Welsh, R. C.; Wiggins, J. L.; Jaeggi, S. M.; Buschkuehl, M.; Monk, Christopher S.; Jonides, J. and Peltier, S. J. (2012). Resting State Cortico-Cerebellar Functional Connectivity Networks: A Comparison of Anatomical and Self-Organizing Map Approaches. Frontiers in Neuroanatomy, 6, 31.
- Wiggins, J. L.; Peltier, S. J.; Ashinoff, S.; Weng, S. J.; Carrasco, M.; Welsh, R. C.; Lord, C.; Monk, Christopher S. and Monk, Christopher S. (2011). Using a Self-Organizing Map Algorithm to Detect Age-Related Changes in Functional Connectivity during Rest in Autism Spectrum Disorders. Brain Research, 1380, 187-197.
- Weng, S. J.; Carrasco, M.; Swartz, J. R.; Wiggins, J. L.; Kurapati, N.; Liberzon, I.; Risi, S.; Lord, C. and Monk, Christopher S. (2011). Neural Activation to Emotional Faces in Adolescents with Autism Spectrum Disorders. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 52(3), 296-305.
- Swartz, JohnnaR; Graham-Bermann, SandraA; Mogg, Karin; Bradley, BrendanP and Monk, Christopher S. (2011). Attention Bias to Emotional Faces in Young Children Exposed to Intimate Partner Violence. Biological Psychiatry, 4(2), 109-122.
- Maslowsky, Julie; Keating, Daniel P.; Monk, Christopher S. and Schulenberg, John E. (2011). Planned Versus Unplanned Risks: Neurocognitive Predictors of Subtypes of Adolescents’ Risk Behavior. International Journal of Behavioral Development, 35(2), 152-160.
- Monk, Christopher S.; Weng, S. J.; Wiggins, J. L.; Kurapati, N.; Louro, H. M.; Carrasco, M.; Maslowsky, J.; Risi, S. and Lord, C. (2010). Neural Circuitry of Emotional Face Processing in Autism Spectrum Disorders. Journal of Psychiatry & Neuroscience : JPN, 35(2), 105-114.
- Weng, S. J.; Wiggins, J. L.; Peltier, S. J.; Carrasco, M.; Risi, S.; Lord, C. and Monk, Christopher S. (2010). Alterations of Resting State Functional Connectivity in the Default Network in Adolescents with Autism Spectrum Disorders. Brain Research, 1313, 202-214.
- Biswal, B. B.; Mennes, M.; Zuo, X. N.; Gohel, S.; Kelly, C.; Smith, S. M.; Beckmann, C. F.; Adelstein, J. S.; Buckner, R. L.; Colcombe, S.; Dogonowski, A. M.; Ernst, M.; Fair, D.; Hampson, M.; Hoptman, M. J.; Hyde, J. S.; Kiviniemi, V. J.; Kotter, R.; Li, S. J.; Lin, C. P.; Lowe, M. J.; Mackay, C.; Madden, D. J.; Madsen, K. H.; Margulies, D. S.; Mayberg, H. S.; McMahon, K.; Monk, Christopher S.; Mostofsky, S. H.; Nagel, B. J.; Pekar, J. J.; Peltier, S. J.; Petersen, S. E.; Riedl, V.; Rombouts, S. A.; Rypma, B.; Schlaggar, B. L.; Schmidt, S.; Seidler, R. D.; Siegle, G. J.; Sorg, C.; Teng, G. J.; Veijola, J.; Villringer, A.; Walter, M.; Wang, L.; Weng, X. C.; Whitfield-Gabrieli, S.; Williamson, P.; Windischberger, C.; Zang, Y. F.; Zhang, H. Y.; Castellanos, F. X. and Milham, M. P. (2010). Toward Discovery Science of Human Brain Function. Proceedings of the National Academy of Sciences of the United States of America, 107(10), 4734-4739.
- Thomason, M. E.; Henry, M. L.; Paul Hamilton, J.; Joormann, J.; Pine, D. S.; Ernst, M.; Goldman, D.; Mogg, K.; Bradley, B. P.; Britton, J. C.; Lindstrom, K. M.; Monk, Christopher S.; Sankin, L. S.; Louro, H. M. and Gotlib, I. H. (2010). Neural and Behavioral Responses to Threatening Emotion Faces in Children as a Function of the Short Allele of the Serotonin Transporter Gene. Biological Psychology, 85(1), 38-44.
- Maslowsky, J.; Mogg, K.; Bradley, B. P.; McClure-Tone, E.; Ernst, M.; Pine, D. S. and Monk, Christopher S. (2010). A Preliminary Investigation of Neural Correlates of Treatment in Adolescents with Generalized Anxiety Disorder. Journal of Child and Adolescent Psychopharmacology, 20(2), 105-111.
- Vasa, R. A.; Pine, D. S.; Masten, C. L.; Vythilingam, M.; Collin, C.; Charney, D. S.; Neumeister, A.; Mogg, K.; Bradley, B. P.; Bruck, M. and Monk, Christopher S. (2009). Effects of Yohimbine and Hydrocortisone on Panic Symptoms, Autonomic Responses, and Attention to Threat in Healthy Adults. Psychopharmacology, 204(3), 445-455.
- Monk, Christopher S.; Peltier, S. J.; Wiggins, J. L.; Weng, S. J.; Carrasco, M.; Risi, S. and Lord, C. (2009). Abnormalities of Intrinsic Functional Connectivity in Autism Spectrum Disorders. Neuroimage, 47(2), 764-772.
- Lindstrom, K. M.; Guyer, A. E.; Mogg, K.; Bradley, B. P.; Fox, N. A.; Ernst, M.; Nelson, E. E.; Leibenluft, E.; Britton, J. C.; Monk, Christopher S.; Pine, D. S. and Bar-Haim, Y. (2009). Normative Data on Development of Neural and Behavioral Mechanisms Underlying Attention Orienting Toward Social-Emotional Stimuli: An Exploratory Study. Brain Research, 1292, 61-70.
- Beesdo, K.; Lau, J. Y.; Guyer, A. E.; McClure-Tone, E. B.; Monk, Christopher S.; Nelson, E. E.; Fromm, S. J.; Goldwin, M. A.; Wittchen, H. U.; Leibenluft, E.; Ernst, M. and Pine, D. S. (2009). Common and Distinct Amygdala-Function Perturbations in Depressed Vs Anxious Adolescents. Archives of General Psychiatry, 66(3), 275-285.
- Lau, J. Y.; Goldman, D.; Buzas, B.; Fromm, S. J.; Guyer, A. E.; Hodgkinson, C.; Monk, Christopher S.; Nelson, E. E.; Shen, P. H.; Pine, D. S. and Ernst, M. (2009). Amygdala Function and 5-HTT Gene Variants in Adolescent Anxiety and Major Depressive Disorder. Biological Psychiatry, 65(4), 349-355.
- Telzer, E. H.; Mogg, K.; Bradley, B. P.; Mai, X.; Ernst, M.; Pine, D. S. and Monk, Christopher S. (2008). Relationship between Trait Anxiety, Prefrontal Cortex, and Attention Bias to Angry Faces in Children and Adolescents. Biological Psychology, 79(2), 216-222.
- Monk, Christopher S. and Pine, D. S. (2008). Cognitive Factors in Depressive Disorders: A Developmental Perspective. In Allen,N. and Sheeber,L. (Ed.), Adolescent Emotional Development and the Emergence of Depressive Disorders.. Cambridge University Press:New York.
- Monk, Christopher S. and Pine, D. S. (2008). Childhood Anxiety Disorders: A Cognitive Neurobiological Perspective. In Charney,D. S.; Nestler,E. J. and Bunney,B. S. (Ed.), Neurobiology of Mental Illness. Oxford University Press:New York, NY.
- Pine, D. S. and Monk, Christopher S. (2008). Anxiety Disorders. In Nelson,D. A. and Luciana,M. (Ed.), Handbook of Developmental Cognitive Neuroscience. MIT Press:Cambridge, MA.
- Monk, Christopher S.; Telzer, E. H.; Mogg, K.; Bradley, B. P.; Mai, X.; Louro, H. M.; Chen, G.; McClure-Tone, E. B.; Ernst, M. and Pine, D. S. (2008). Amygdala and Ventrolateral Prefrontal Cortex Activation to Masked Angry Faces in Children and Adolescents with Generalized Anxiety Disorder. Archives of General Psychiatry, 65(5), 568-576.
- Monk, Christopher S. (2008). The Development of Emotion-Related Neural Circuitry in Health and Psychopathology. Development and Psychopathology, 20(4), 1231-1250.
- Masten, C. L.; Guyer, A. E.; Hodgdon, H. B.; McClure, E. B.; Charney, D. S.; Ernst, M.; Kaufman, J.; Pine, D. S. and Monk, Christopher S. (2008). Recognition of Facial Emotions among Maltreated Children with High Rates of Post-Traumatic Stress Disorder. Child Abuse & Neglect, 32(1), 139-153.
- Guyer, A. E.; Monk, Christopher S.; McClure-Tone, E. B.; Nelson, E. E.; Roberson-Nay, R.; Adler, A. D.; Fromm, S. J.; Leibenluft, E.; Pine, D. S. and Ernst, M. (2008). A Developmental Examination of Amygdala Response to Facial Expressions. Journal of Cognitive Neuroscience, 20(9), 1565-1582.