ABSTRACT Objective: The purpose of this study was to identify and compare the differences in perceived barriers for mammography screening among four ethnic groups of Asian-American women. Methods: Self-administered questionnaires were completed by 315 women in these four groups. Results: The results from the multivariate analyses indicated that even after taking into account insurance coverage and demographic variables, specific barriers still prevent Asian-American women from seeking mammography. Discussion: Recognizing similarities and differences in the barriers among demographic variables such as ethnicity, age, and length of U.S. residency among Asian subgroups can assist health professionals to address their needs when promoting adherence to mammography guidelines.; ABSTRACT Objective: The purpose of this study was to identify and compare the differences in perceived barriers for mammography screening among four ethnic groups of Asian-American women. Methods: Self-administered questionnaires were completed by 315 women in these four groups. Results: The results from the multivariate analyses indicated that even after taking into account insurance coverage and demographic variables, specific barriers still prevent Asian-American women from seeking mammography. Discussion: Recognizing similarities and differences in the barriers among demographic variables such as ethnicity, age, and length of U.S. residency among Asian subgroups can assist health professionals to address their needs when promoting adherence to mammography guidelines.