JOBS is a research-based program delivered in a group format and designed to aid unemployed job seekers in their search for employment. The program has demonstrated positive impacts on job-search skills, motivation, reemployment rates, and mental health. The JOBS program was designed and tested in large-scale randomized trials at the Institute for Social Research at the University of Michigan. The positive effect of JOBS has been replicated in a number of national and international settings. Research, theory, and principles for best practice in the implementation of JOBS are discussed, as well as future directions for research and new applications.